Diblock Copolypeptide Amphiphiles Form Rapidly Recovering Hydrogels
نویسندگان
چکیده
منابع مشابه
Blending of diblock and triblock copolypeptide amphiphiles yields cell penetrating vesicles with low toxicity.
We prepared dual hydrophilic triblock copolypeptide vesicles that form both micron and nanometer scale vesicles in aqueous media. The incorporation of terminal homoarginine segments into methionine sulfoxide-based vesicles was found to significantly enhance their cellular uptake compared to a non-ionic control. We also demonstrated that diblock and triblock copolypeptides with similar hydrophob...
متن کاملEffect of chemistry and morphology on the biofunctionality of self-assembling diblock copolypeptide hydrogels.
Amphiphilic, diblock copolypeptides of hydrophilic lysine or glutamic acid and hydrophobic leucine or valine have been observed to self-assemble into rigid hydrogels in aqueous solution at neutral pH and very low volume fraction of polymer, > or =0.5 wt % polypeptide. Laser scanning confocal microscopy and ultra small angle neutron scattering revealed a heterogeneous microstructure with distinc...
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Amphiphilic block copolypeptides were prepared through transition-metal-mediated polymerization of amino acid N-carboxyanhydrides. In aqueous solution these materials form strong hydrogels at low concentrations. The self-assembly process that is responsible for gelation was investigated by measuring the rheological properties of the gels for a variety of molecular architectures: poly-L-lysineb-...
متن کاملSelf-Assembly of Discrete Metal Complexes in Aqueous Solution via Block Copolypeptide Amphiphiles
The integration of discrete metal complexes has been attracting significant interest due to the potential of these materials for soft metal-metal interactions and supramolecular assembly. Additionally, block copolypeptide amphiphiles have been investigated concerning their capacity for self-assembly into structures such as nanoparticles, nanosheets and nanofibers. In this study, we combined the...
متن کاملUnusual salt stability in highly charged diblock co-polypeptide hydrogels.
The stability and properties of dilute solution hydrogels, synthesized by transition metal mediated polymerization of amino acid N-carboxyanhydrides (NCAs), have been studied in deionized (DI) water as well as various ionic media. These hydrogels are diblock amphiphilic copolymers of hydrophilic, charged segments of poly(l-lysine HBr) or poly(l-glutamic acid sodium salt), and helical, hydrophob...
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ژورنال
عنوان ژورنال: MRS Bulletin
سال: 2002
ISSN: 0883-7694,1938-1425
DOI: 10.1557/mrs2002.183